The Origin and Onset of Thrombus Disease: collapsed balancing function of immune cells and triggering factors 血栓病的起源与发生:免疫细胞平衡功能崩溃与启动机制

封面

版权页

About the Author

Preface

Acknowledgment

Introduction

Part I Venous thrombus

Chapter 1 The origin and onset of acute venous thrombus

Chapter 2 The answer to the onset of acute venous thrombus

1.Questions from clinics

2.Protein components analysis of acute venous thrombus

3.Localization of core proteins in acute venous thrombus

4.Inevitability of building a new intravenous defense line

5.Significant downregulation of human immune system related gene mRNA expressions

6.DNA sequence mutation in familial VTE patients

7.Immune cell function with VTE

8.Malignancy and VTE

9.Expression of same / different proteins in venous thromboembolism and different risk factor group patients

10.Core proteins may serve as new specific protein markers for VTE diagnosis

References

Chapter 3 Components of acute venous red thrombus

1.Pathology of acute venous thrombus

2.Main protein components of acute venous thrombus

3.Core proteins in acute venous thrombus

4.The inflammatory immune adherence is involved in the whole process of acute venous thrombosis

5.Nest-like biological venous filter within acute venous red thrombus

6.Venous Thrombosis is a product in proliferation of cancer cells

Chapter 4 Cytological detection of core proteins

1.A New marker for diagnosis of VTE

2.Increased expressions of integrin subunits β1 β2 and β3 in patients with acute infection

3.Increased expressions of integrin subunits β1 β2 and β3 in patients with cancer

4.Expression of the same or different proteins in venous thromboembolism and different risk factor group patients

Chapter 5 Venous thrombus and pathogenic microorganism

1.Severe Acute Respiratory Syndrome and VTE in multiple organs

2.Virus-like structure in a patient with pulmonary hypertension and VTE

3.Bacteremia and the occurrence of VTE in multiple organs

Chapter 6 Function and regulation of the immune system

1.Immune function

2.Factors affecting immune cell functions

References

Chapter 7 General theory of genomics in patients with symptomatic pulmonary thromboembolism (PE)

1.Pandect—Network analysis of human genome differences

2.Systematics of genomics

Chapter 8 Characterization of immune cell perforin mutations in a family with VTE

Clinical data of this Chinese family

Exon capture and next-generation sequencing

Sequence mapping and single nucleotide variation identification

Examining PRF1 HTR2A and ABCC8 mutations in control individuals

Examination of differentiation antigens on immune cells

Detection of complement components

Exome Sequencing

Mutations of 2 genes predicted to be functionally damaged

References

Chapter 9 VTE and immune cell dysfunction

1.The patients with acute PE and Dysfunction of CD3CD8 T cells

2.T cell-mediated immune deficiency in patients with CTEPH

3.Symptomatic VTE is a disease related to infection and immune dysfunction

4.Acute VTE and high expression of CH50

Part II Arterial thrombus

Chapter 10 New viewpoints on the pathogenesis of acute arterial thrombosis

References

Chapter 11 Human genomics in patients with acute myocardial infarction—pandect

Acute arterial thrombosis and differentially expressed genes—Significantly reduced function of T cells

Patient information

Gene expression chips

Total RNA isolation

RNA amplification and labeling

Microarray hybridization

Chip scan and Data acquisition

RT-PCR

Data analysis

Results

References

Chapter 12 Human genomics in patients with acute myocardial infarction

1.Expression characteristics of neutrophil and mononuclearphagocyte related genes in patients with AMI and SAP

2.Expression characteristics of natural killer cell related genes mRNA in patients with AMI and SAP

3.Expression characteristics of complement system related genes in patients with AMI and SAP

4.Expression characteristics of cytokine related genes in patients with AMI and SAP

5.Expression characteristics of T cell related genes in AMI and SAP patients

6.Expression characteristics of B cell related genes in patients with AMI and SAP

7.Comparison of gene expression of Integrin β2 between AMI and SAP patients

Chapter 13 The impaired innate and adaptive immunity in patients with coronary artery diseases

Part III Summary and prospect

Chapter 14 Differences of origin and onset between acute venous and arterial thrombus

1.Gist of acute venous thrombosis

2.Gist of acute arterial thrombosis

3.Similarities and differences of internal and external factors between acute venous and arterial thrombosis