参考文献
[1]Runge VM，Clanton JA，Herzer WA，et al.Intravascular contrast agents suitable for magnetic resonance imaging.Radiology，1984，153（1）：171-176.
[2]Dujardin MI，Sourbron SP，Chaskis C，et al.Quantification of cerebral tumour blood flow and permeability with T1-weighted dynamic contrast enhanced MRI：a feasibility study.J Neuroradiol，2012，39（4）：227-235.
[3]Johnson G，Wetzel SG，Cha S，et al.Measuring blood volume and vascular transfer constant from dynamic，T（2）∗-weighted contrast-enhanced MRI.Magn Reson Med，2004，51（5）：961-968.
[4]卢光明，杨刚，张福琛，等.动态增强 MRI诊断垂体微腺瘤的研究.中华放射学杂志，1996，30（5）：329-332.
[5]Agner SC，Rosen MA，Englander S，et al.Computerized image analysis for identifying triple-negative breast cancers and differentiating them from other molecular subtypes of breast cancer on dynamic contrast-enhanced MR images：a feasibility study.Radiology，2014，272（1）：91-99.
[6]Tofts PS，Kermode AG.Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging.1.Fundamental concepts.Magn Reson Med，1991，17（2）：357-367.
[7] Li L，Wang K，Sun X，et al.Parameters of dynamic contrast-enhanced MRI as imaging markers for angiogenesis and proliferation in human breast cancer. Med Sci Monit，2015，21：376-382.
[8]Pickles MD，Lowry M，Manton DJ，et al.Prognostic value of DCE-MRI in breast cancer patients undergoing neoadjuvant chemotherapy：a comparison with traditional survival indicators.Eur Radiol.2015，25（4）：1097-1106.
[9]Schacht DV，Drukker K，Pak I，et al.Using quantitative image analysis to classify axillary lymph nodes on breast MRI：A new application for the Z 0011 Era.Eur J Radiol，2015，84（3）：392-397.
[10]Yang Q，Li L，Zhang J，et al.A new quantitative image analysis method for improving breast cancer diagnosis using DCE-MRI examinations.Med Phys，2015，42（1）：103-109.
[11]张晓琦，李永丽，窦社伟，等.动态对比增强MRI在胶质母细胞瘤与脑转移瘤鉴别诊断中的应用.中华放射学杂志，2015，（6）：410-413.
[12]van Lin EN，Futterer JJ，Heijmink SW，et al.IMRT boost dose planning on dominant intraprostatic lesions：gold marker-based three-dimensional fusion of CT with dynamic contrast-enhanced and 1H-spectroscopic MRI.Int J Radiat Oncol Biol Phys，2006，65（1）：291-303.
[13]Chen H，Wu B，Zhu G，et al.Permeability Imaging as a Biomarker of Leptomeningeal Collateral Flow in Patients with Intracranial Arterial Stenosis.Cell Biochem Biophys，2015，71（3）：1273-1279.
[14]Jiji RS，Pollak AW，Epstein FH，et al.Reproducibility of rest and exercise stress contrast-enhanced calf perfusion magnetic resonance imaging in peripheral arterial disease.J Cardiovasc Magn Reson，2013； 15：14.
[15]Taheri S，Gasparovic C，Huisa BN，et al.Blood-brain barrier permeability abnormalities in vascular cognitive impairment.Stroke，2011，42（8）：2158-2163.
[16]Wardlaw JM，Doubal F，Armitage P，et al.Lacunar stroke is associated with diffuse blood-brain barrier dysfunction.Ann Neurol，2009，65（2）：194-202.
[17]Moreno PR，Purushothaman KR，Sirol M，et al.Neovascularization in human atherosclerosis.Circulation，2006，113（18）：2245-2252.
[18]Li W，Long JA，Watts LT，et al.A quantitative MRI method for imaging blood-brain barrier leakage in experimental traumatic brain injury.PLoS One，2014，9（12）：e114173.
[19]Cramer SP，Larsson HB.Accurate determination of blood-brain barrier permeability using dynamic contrastenhanced T1-weighted MRI：a simulation and in vivo study on healthy subjects and multiple sclerosis patients.J Cereb Blood Flow Metab，2014，34（10）：1655-1665.
[20]Chen BB，Hsu CY，Yu CW，et al.Dynamic contrast-enhanced magnetic resonance imaging with Gd-EOB-DTPA for the evaluation of liver fibrosis in chronic hepatitis patients.Eur Radiol，2012，22（1）：171-180.
[21]Vordenbaumen S，Schleich C，Logters T，et al.Dynamic contrast-enhanced magnetic resonance imaging of metacarpophalangeal joints reflects histological signs of synovitis in rheumatoid arthritis.Arthritis Res Ther，2014，16（5）：452.
[22]Cimmino MA，Parodi M，Zampogna G，et al.Dynamic contrast-enhanced，extremity-dedicated MRI identifies synovitis changes in the follow-up of rheumatoid arthritis patients treated with rituximab.Clin Exp Rheumatol，2014，32（5）：647-652.
[23]O’Connor JP，Jackson A，Parker GJ，et al.Dynamic contrast-enhanced MRI in clinical trials of antivascular therapies.Nat Rev Clin Oncol，2012，9（3）：167-177.
[24]Wong CI，Koh TS，Soo R，et al.Phase I and biomarker study of ABT-869，a multiple receptor tyrosine kinase inhibitor，in patients with refractory solid malignancies.J Clin Oncol，2009，27（28）：4718-4726.
[25]Chen Z，Yin JJ，Zhou YT，et al.Dual enzyme-like activities of iron oxide nanoparticles and their implication for diminishing cytotoxicity.ACS Nano，2012，6（5）：4001-4012.
[26]Sottoriva A，Spiteri I，Piccirillo SG，et al.Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics.Proc Natl Acad Sci U S A.2013，110（10）：4009-4014.
[27]Padhani AR，Hayes C，Assersohn L，et al.Prediction of clinicopathologic response of breast cancer to primary chemotherapy at contrast-enhanced MR imaging：initial clinical results.Radiology.2006，239（2）：361-374.
[28]Johansen R，Jensen LR，Rydland J，et al.Predicting survival and early clinical response to primary chemotherapy for patients with locally advanced breast cancer using DCE-MRI.J Magn Reson Imaging.2009，29（6）：1300-1307.
[29]Jensen RL，Mumert ML，Gillespie DL，et al.Preoperative dynamic contrast-enhanced MRI correlates with molecular markers of hypoxia and vascularity in specific areas of intratumoral microenvironment and is predictive of patient outcome.Neuro Oncol.2014，16（2）：280-291.
[30]Horsman MR，Mortensen LS，Petersen JB，et al.Imaging hypoxia to improve radiotherapy outcome.Nat Rev Clin Oncol.2012，9（12）：674-687.
[31]Fukumura D，Jain RK.Tumor microenvironment abnormalities：causes，consequences，and strategies to normalize.J Cell Biochem.2007，101（4）：937-949.
[32]Hompland T，Gulliksrud K，Ellingsen C，et al.Assessment of the interstitial fluid pressure of tumors by dynamic contrast-enhanced magnetic resonance imaging with contrast agents of different molecular weights.Acta Oncol，2013，52（3）：627-635.
[33]Hompland T，Ellingsen C，Ovrebo KM，et al.Interstitial fluid pressure and associated lymph node metastasis revealed in tumors by dynamic contrast-enhanced MRI.Cancer Res，2012，72（19）：4899-4908.